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A novel human pain insensitivity disorder – “A Family That Doesn’t Feel Pain”

January 4, 2018

Lead study author Dr James Cox, from University College London, said the Marsili family members had all their nerves present, but “they’re just not working how they should be.”  He said: “We’re working to gain a better understanding of exactly why they don’t feel much pain, to see if that could help us find new pain relief treatments.”  The research team, whose findings are published in the journal Brain, worked with the family to find out the nature of their phenotype – the observable characteristics caused by their genetics.  The Marsili syndrome, named after them, means the affected individuals are less than normally sensitive (or hyposensitive) to extreme heat, capsaicin in chilli peppers and have experienced pain-free bone fractures.  Read the entire article here.

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